Course description
This course aims to provide you with the skills and knowledge of theory and practice that will enable you to work as a professional capable of making important contributions in the field of clinical biochemistry. The course aims to further enhance your knowledge of clinical biochemistry, to engage you with contemporary issues and debates within the discipline, and to develop your critical and analytical skills.
The taught programme contains specific modules in Clinical Biochemistry, such as endocrinology and metabolism and diagnostic clinical biochemistry, which you can apply to diagnostic biomedicine, as well as offering you a choice of modules related to molecular diagnostics or haematology.
Modules:
The following modules are indicative of what you will study on this course. For more details on course structure and modules, and how you will be taught and assessed, see the full course document.
Core modules:
CLINICAL ENDOCRINOLOGY AND METABOLISM
This module aims to emphasise the intellectual skills and knowledge you require to understand endocrine function, assays of hormone concentration, pathologies and their laboratory investigation. Emphasis is placed on developing a deep understanding of the cellular and biochemical processes which underlie pathology
DIAGNOSTIC CLINICAL BIOCHEMISTRY
An in depth study of the aetiology, pathogenesis and laboratory investigation of selected pathologies and their laboratory investigation. Principles of key and current analytical methods in the field are also included as well as the latest developments in diagnostic clinical biochemistry.
MOLECULAR SCIENCE AND DIAGNOSTICS
This module is designed to make you aware of the impact of molecular biology on the diagnosis of human diseases. You will critically review the technologies and determine the advantages and disadvantages associated with each diagnostic strategy. Issues of accuracy, implementation, ethics and safety will be addressed.
POSTGRADUATE RESEARCH METHODS
You will be able to develop your skills in information retrieval, critical analysis and presentation relevant to your research topic, and form a clear plan for your project.
POSTGRADUATE PROJECT
This module aims to enhance your skills of self-management, experimental design, critical analysis and interpretation of data, enabling you to present and justify your research.
Option modules:
AUTOMATION IN BIOMEDICAL SCIENCES
This module will explore the current and potential impact of laboratory automation on the practice of biomedical science in the context of diagnosis and research. You will explore automation from the perspectives of technology, quality, impact on skill requirements, cost/benefit and laboratory organisation. The module will include site visits to laboratories using state-of-the-art automation.
CELL SIGNALLING AND GENETICS
This module provides up-to-date information on cell signalling processes coupling surface receptor engagement to changes in gene expression. Transcriptional, post-transcriptional and post-translational mechanisms are discussed in relation to selected cell-signalling pathways responsible for controlling cell functions such as cell cycle, cell differentiation and cell death. Examples of defective cell signalling through inherited and somatically acquired mutations in signalling components will be highlighted in relation to human disease.
CELLULAR HAEMATOLOGY
This module will enable you to understand how blood cells are produced and how they function in normal and pathological situations. You will consider the causes, consequences and laboratory features of a range of red cell disorders and haematological malignancies, and be able to evaluate and interpret the relevant diagnostic testing procedures.
COMMUNICATING SCIENCE
Introducing you to key concepts in science communication, its challenges, rewards and applications, this module is designed to incorporate scenarios related to your interests, such as health, drug discovery and water science. The roles of science and scientists in society and how the public perceives, interacts with and responds to the information produced by scientists are explored, with the history of communicating science used to contextualise current issues in disseminating information.
IMMUNOHAEMATOLOGY AND HAEMOSTASIS
This module will cover clinically important blood group systems and laboratory techniques used to identify blood group antigens and antibodies, and to ensure safety of blood components for transfusion and transplantation. In addition you will examine the various components of the haemostasis system together with clinical disorders leading to increased risk of bleeding or thrombosis. Anticoagulant therapy and relevant laboratory techniques for investigation of haemostasis will also be covered.
IMMUNOPATHOLOGY
You will analyse and discuss cellular and molecular aspects of innate and adaptive immune responses, and advances in modern methods for disease diagnosis and treatment. This will include strategies available for the diagnosis of inherited and acquired immunological disorders, normal and pathological immune responses to extracellular and intracellular pathogens, transplantation of organs and tissues, immune surveillance of tumours, autoimmune and immunodeficiency disorders.
PRINCIPLES OF MOLECULAR MEDICINE
The module provides you with a critical appreciation of the human genome, its regulation, functional significance of gene mutations and current approaches of identification of human genetic disorders. Topics covered include: molecular basis of host-pathogen interaction; molecular pathology of disease with simple genetics; molecular genetics of disease; complex systems, immunogenetics and disease; and molecular genetics of cancer.
